Neuropsychological and functional outcomes in recent-onset major depression, bipolar disorder and schizophrenia-spectrum disorders: A longitudinal cohort study

RSC Lee; DF Hermens; SL Naismith; J Lagopoulos; A Jones; J Scott; KM Chitty; D White; R Robillard; EM Scott; IB Hickie

Journal article

Neuropsychological and functional outcomes in recent-onset major depression, bipolar disorder and schizophrenia-spectrum disorders: A longitudinal cohort study

RSC Lee, DF Hermens, SL Naismith, J Lagopoulos, A Jones, J Scott, KM Chitty, D White, R Robillard, EM Scott, IB Hickie

Translational Psychiatry | SPRINGERNATURE | Published : 2015

DOI: 10.1038/tp.2015.50

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Abstract

Functional disability is the lead contributor to burden of mental illness. Cognitive deficits frequently limit functional recovery, although whether changes in cognition and disability are longitudinally associated in recent-onset individuals remains unclear. Using a prospective, cohort design, 311 patients were recruited and assessed at baseline. One hundred and sixty-seven patients met eligibility criteria (M = 21.5 years old, s.d. = 4.8) and returned for follow-up (M = 20.6 months later, s.d. = 7.8). Two-hundred and thirty participants were included in the final analysis, comprising clinically stable patients with major depression (n = 71), bipolar disorder (BD; n =61), schizophrenia-spec..

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University of Melbourne Researchers

Rico Lee Author

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Awarded by AstraZeneca

Funding Acknowledgements

RSCL was supported by funding from the National Health and Medical Research Council Centre of Research Excellence in Optimising Early Interventions for Young People with Emerging Mood Disorders (no. 1061043). IBH was funded by a National Health and Medical Research Council Program Grant (no. 566529) and Australian Fellowship (no. 464914). DFH was supported by a grant from NSW Health Mental Health and Drug and Alcohol Office. SLN was funded by a National Health and Medical Research Council Clinical Development Award (no. 1008117). RR received a postdoctoral training award from the Fonds de la recherche en sante du Quebec. These funding agencies had no further role in study design, collection, analysis and interpretation of data, writing of the report and decision to submit the paper for publication.